apalutamide will lessen the level or result of triazolam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with prescription drugs that are CYP3A4 substrates may result in decreased exposure to those medicines.bosentan will decrease the extent or